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eBook Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk (Environmental Science Research) ePub

eBook Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk (Environmental Science Research) ePub

by F.J. De Serres

  • ISBN: 0306413809
  • Category: Medicine
  • Subcategory: Medicine
  • Author: F.J. De Serres
  • Language: English
  • Publisher: Springer; 1983 edition (August 1, 1983)
  • Pages: 341
  • ePub book: 1222 kb
  • Fb2 book: 1640 kb
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  • Rating: 4.9
  • Votes: 810

Description

Applications in Genetic Risk Estimation of Data on the Induction of Dominant Skeletal Mutations in Mice.

Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. Authors: De Serres, . These do not, however, meet the re­ quirements for extensive laboratory studies. Applications in Genetic Risk Estimation of Data on the Induction of Dominant Skeletal Mutations in Mice.

Applications in Genetic Risk Estimation of Data on the Induction of Dominant Skeletal Mutations in Mice. Published: 1 January 1983. by Springer Science and Business Media LLC. in Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk pp 211-226; doi:10. The publisher has not yet granted permission to display this abstract.

For studies of genetic effects, some non-invasive human test systems are presently . Applications in Genetic Risk Estimation of Data.

These do not, however, meet the re quirements for extensive laboratory studies. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. 191. Detection of Enzyme Activity Variants in Mice.

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de serres f. j. & sheridan w. 1983 utilization of mammalian specific locus studies in hazard evaluation and estimation of genetic risk. We guarantee the condition of every book as it's described on the Abebooks web sites. January 1985 · Journal of Medical Genetics. Field Studies: Aquatic Systems. Bioassessment Methods for Determining the Hazards of Dredged Material Disposal in the Marine Environment. Use of Herring Embryos for In Situ and In Vitro Monitoring of Maring Pollution. New Methods for On-Site Biological Monitoring of Effluent Water Quality. Micronucleus Test Using Peripheral Red Blood Cells of Amphibian Larvae for Detection of Genotoxic Agents in Freshwater Pollution.

Genetic heterogeneity in mammalian specific-locus mutation systems

Genetic heterogeneity in mammalian specific-locus mutation systems. Environmental and Molecular Mutagenesis, Vol. 26, Issue. Cataracts - indicators for dominant mutations in mice and man. In Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk (ed. de Serres, F. and Sheridan, ., pp. 169–190. Ehling, U. H. & Neuhäuser, A. (1979). Favor, . Kratochvilova, J. & Neuhäuser-Klaus, A. (1982).

tion Rate Increase, Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk, . deSerres and W. Sheridan (ed. (New York: Plenum Press, 1983), PP. 95-123. 53. Johnson, F, . Roberts, G. Sharma, R. et a. The Detection of Mutants in Mice by Elec-trophoresis: Results of a Model Induction Exper-iment With Procarbazine, Genetics 97:113-124, 1981.

Such studies clearly demonstrate the potential of emnironmental chemicals to induce mutations in both somatic and .

Such studies clearly demonstrate the potential of emnironmental chemicals to induce mutations in both somatic and reproductive cells of mammals. This NIEHS program has become a leader in the identification of genetic hazards in the environment and in the acquisition of animal model data used by regulatory agencies in assessing genetic risks to human health. The Human Health Issue Genetically based diseases have a major impact on human health.

The magnitude of the threat to the human genetic material posed by. .of many chemicals have been identi- fied by studies on lower organisms. The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Never- theless, the potential hazards of many chemicals have been identi- fied by studies on lower organisms.

The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Never­ theless, the potential hazards of many chemicals have been identi­ fied by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the re­ quirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investiga­ tions are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests.